Eosinophil trafficking in asthma
نویسندگان
چکیده
منابع مشابه
Eosinophil trafficking in asthma.
Asthma is characterised by a 50-fold increase in the number of eosinophils relative to neutrophils in the bronchial mucosa. This is the result of the cumulative and sequential effects of several, approximately fourfold, increases in selective eosinophil versus neutrophil migration occurring at a number of stages in the life cycle of the eosinophil. These events, which are integrated and directe...
متن کاملRegulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma
Asthma is an inflammatory disease usually characterized by increased Type 2 cytokines and by an infiltration of eosinophils to the airways. While the production of Type 2 cytokines has been associated with TH2 lymphocytes, increasing evidence indicates that group 2 innate lymphoid cells (ILC2) play an important role in the production of the Type 2 cytokines interleukin (IL)-5 and IL-13, which l...
متن کاملEndothelial prostaglandin I2 restrains eosinophil trafficking
Background Enhanced eosinophil extravasation into the tissue is a characteristic feature of bronchial asthma and other allergic diseases. The barrier-forming vascular endothelial cells release prostaglandin I2 (PGI2, prostacyclin) as the major prostanoid, and it has been previously observed that PGI2 receptor (IP)-deficient mice show enhanced eosinophilic inflammation in response to allergens. ...
متن کاملEosinophil Apoptosis and Clearance in Asthma
Asthma is an increasingly common respiratory condition characterized by reversible airway obstruction, bronchial hyper-responsiveness and airway inflammation with a clear unmet need for more effective therapy. Eosinophilic asthma is a phenotype of the condition that features increased blood or sputum eosinophils whose numbers correlate with disease severity. Several lines of evidence are now em...
متن کاملCirculating eosinophil progenitors express major trafficking related molecules and are more activated compared to mature eosinophils in patients with asthma
Background Eosinophilic inflammation represents a hallmark for allergic asthma. Eosinophils differentiate in the bone marrow from CD34+ cells and are released into the blood and traffic to the lung tissue. To date, the majority of studies originate from animal models or from humans after allergen exposure. Thus, it is unclear if mature eosinophils and eosinophil progenitors express similar leve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2001
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.1-3-214